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Dokument 2561Titel:
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Warning: Use of undefined constant titel_deutsch - assumed 'titel_deutsch' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 528

Warning: Use of undefined constant titel_englisch - assumed 'titel_englisch' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 528
Preclinical safety evaluation of cerivastatin, a novel HMG-CoA reductase inhibitor
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Warning: Use of undefined constant bereiche - assumed 'bereiche' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 530

Bereich:
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Toxikologie
Tiere:
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Warning: Use of undefined constant tierart_id - assumed 'tierart_id' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 533
Tiere verschiedener Arten (Anzahl unbekannt)
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(
Warning: Use of undefined constant tierdetails - assumed 'tierdetails' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 536
Hunde, Mäuse, Ratten, Affen, Kaninchen (Anzahl unbekannt))
Jahr: 1998

Versuchsbeschreibung:
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Die Giftigkeit eines Mittels zur Senkung des Cholesterinspiegels wird über einen Zeitraum von 4 Wochen bis 24 Monate an verschiedenen Tierarten getestet.

Bereich:
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Warning: Use of undefined constant bereiche - assumed 'bereiche' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 543
Toxikologie

Originaltitel: Preclinical safety evaluation of cerivastatin, a novel HMG-CoA reductase inhibitor

Autoren:
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Eckhard von Keutz (1)* , Gerhard Schlüter (1)

Institute:
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(1)*Bayer AG, Wuppertal

Zeitschrift:
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American Journal of Cardiology 1998: 82, 11J-17J

Land:
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Deutschland

Art der Veröffentlichung:
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Fachzeitschrift

Dokumenten-ID:
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2575


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Dokument 2562Titel:
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Warning: Use of undefined constant titel_deutsch - assumed 'titel_deutsch' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 528

Warning: Use of undefined constant titel_englisch - assumed 'titel_englisch' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 528
Serotonin (5-HT1A-receptor) agonist-induced collecting duct vacuolation and renal papillary necrosis in the rat
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Warning: Use of undefined constant bereiche - assumed 'bereiche' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 530

Bereich:
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Pharmakologie, Toxikologie
Tiere:
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Warning: Use of undefined constant tierart_id - assumed 'tierart_id' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 533
Ratten (Anzahl unbekannt)
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(
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Anzahl unbekannt)
Jahr: 1998

Versuchsbeschreibung:
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Es werden 3 Langzeitstudien über jeweils 2 Jahre durchgeführt, bei denen ein Psychopharmakon einmalig per Schlundsonde oder mehrfach im Futter bzw. Trinkwasser verabreicht wird.

Bereich:
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Warning: Use of undefined constant bereiche - assumed 'bereiche' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 543
Pharmakologie, Toxikologie

Originaltitel: Serotonin (5-HT1A-receptor) agonist-induced collecting duct vacuolation and renal papillary necrosis in the rat

Autoren:
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Matthias Rinke (1)* , Ernst M. Bomhard (1) , Heinz Hildebrand (1) , Karl H. Leser (1) , Ingo Loof (1) , Christine Rühl-Fehlert (1)

Institute:
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(1)*Bayer AG, Wuppertal

Zeitschrift:
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Toxicologic Pathology 1998: 26(1), 152-159

Land:
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Deutschland

Art der Veröffentlichung:
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Fachzeitschrift

Dokumenten-ID:
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2574


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Dokument 2563Titel:
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Warning: Use of undefined constant titel_deutsch - assumed 'titel_deutsch' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 528

Warning: Use of undefined constant titel_englisch - assumed 'titel_englisch' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 528
Assessment of pyrethroid-induced paraesthesias: comparison of animal model and human data
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Warning: Use of undefined constant bereiche - assumed 'bereiche' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 530

Bereich:
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Toxikologie
Tiere:
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Warning: Use of undefined constant tieranzahl - assumed 'tieranzahl' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 534

Warning: Use of undefined constant tieranzahl - assumed 'tieranzahl' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 535

Warning: Use of undefined constant tieranzahl - assumed 'tieranzahl' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 535
16
Warning: Use of undefined constant tierart_id - assumed 'tierart_id' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 535
Ratten
Warning: Use of undefined constant tierdetails - assumed 'tierdetails' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 536
(
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mindestens)
Jahr: 1998

Versuchsbeschreibung:
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Ratten müssen ein Schädlingsbekämpfungsmittel bis zu 13 Wochen lang einatmen oder erhalten es über eine Schlundsonde direkt in den Magen.

Bereich:
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Warning: Use of undefined constant bereiche - assumed 'bereiche' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 543
Toxikologie

Originaltitel: Assessment of pyrethroid-induced paraesthesias: comparison of animal model and human data

Autoren:
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Jürgen Pauluhn (1)* , L.H. Machemer (1)

Institute:
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(1)*Bayer AG, Wuppertal

Zeitschrift:
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Toxicology Letters 1998: 96/97, 361-368

Land:
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Deutschland

Art der Veröffentlichung:
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Fachzeitschrift

Dokumenten-ID:
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2573


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Warning: in_array() expects parameter 2 to be array, null given in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 564


Dokument 2564Titel:
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Warning: Use of undefined constant titel_deutsch - assumed 'titel_deutsch' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 528

Warning: Use of undefined constant titel_englisch - assumed 'titel_englisch' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 528
D-glucose - combined chronic toxicicity and carcinogenicity studies in Sprague-Dawley rats and Syrian golden hamsters
Warning: Use of undefined constant hintergrund - assumed 'hintergrund' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 529

Warning: Use of undefined constant bereiche - assumed 'bereiche' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 530

Bereich:
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Toxikologie
Tiere:
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Warning: Use of undefined constant tieranzahl - assumed 'tieranzahl' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 535

Warning: Use of undefined constant tieranzahl - assumed 'tieranzahl' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 535
480
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Tiere verschiedener Arten
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(
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240 Hamster, 240 Ratten)
Jahr: 1998

Versuchsbeschreibung:
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Langzeitstudie (Ratten 26 Monate, Hamster 20 Monate) über die mögliche Giftigkeit bzw. die krebserregenden Eigenschaften von Zucker.

Bereich:
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Warning: Use of undefined constant bereiche - assumed 'bereiche' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 543
Toxikologie

Originaltitel: D-glucose - combined chronic toxicicity and carcinogenicity studies in Sprague-Dawley rats and Syrian golden hamsters

Autoren:
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Ernst M. Bomhard (1)* , H. Bischoff (1) , Harry Mager (1) , F. Krötlinger (1) , B. Schilde (1)

Institute:
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(1)*Bayer AG, Wuppertal

Zeitschrift:
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Drug and Chemical Toxicology 1998: 21(3), 329-353

Land:
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Deutschland

Art der Veröffentlichung:
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Fachzeitschrift

Dokumenten-ID:
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2572


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Dokument 2565Titel:
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Calcium channel blockers and the risk of cancer: a preclinical assessment
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Bereich:
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Toxikologie
Tiere:
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2820
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Tiere verschiedener Arten
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(
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1460 Ratten, 1360 Mäuse)
Jahr: 1998

Versuchsbeschreibung:
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Vier blutdrucksenkende Mittel werden über einen Zeitraum von 2 Jahren auf mögliche krebserregende Eigenschaften getestet.

Bereich:
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Warning: Use of undefined constant bereiche - assumed 'bereiche' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 543
Toxikologie

Originaltitel: Calcium channel blockers and the risk of cancer: a preclinical assessment

Autoren:
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Hans Jürgen Ahr (1)* , Ernst M. Bomhard (1) , Harald Enzmann (1) , Eberhard Karbe (1) , Harry Mager (1) , Erich Sander (1) , Gerhard Schlüter (1)

Institute:
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(1)*Bayer AG, Wuppertal

Zeitschrift:
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Cardiovascular Drugs and Therapy 1998: 12, 157-169

Land:
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Deutschland

Art der Veröffentlichung:
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Fachzeitschrift

Dokumenten-ID:
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2571


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Dokument 2566Titel:
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Laser-Doppler scanning of local cerebral blood flow and reserve capacity and testing of motor and memory functions in a chronic 2-vessel occlusion model in rats
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Bereich:
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Hirnforschung, Neurologie, Schlaganfallforschung
Tiere:
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29
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Ratten
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Jahr: 1998

Versuchsbeschreibung:
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Bei narkotisierten Ratten wird die Blutzufuhr zum Gehirn durch Unterbindung beider Halsschlagadern unterbrochen. Danach wird der Schädel eröffnet und die Blutzirkulation im Gehirn gemessen. Bis zu 6 Wochen nach der Operation müssen die Ratten Gedächtnis- und Bewegungstests absolvieren.

Bereich:
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Warning: Use of undefined constant bereiche - assumed 'bereiche' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 543
Hirnforschung, Neurologie, Schlaganfallforschung

Originaltitel: Laser-Doppler scanning of local cerebral blood flow and reserve capacity and testing of motor and memory functions in a chronic 2-vessel occlusion model in rats

Autoren:
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Peter T. Ulrich (1)* , Stefan-Nikolaus Kroppenstedt (1) , Axel Heimann (1) , Oliver Kempski (1)

Institute:
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(1)*Institut für Neurochirurgische Pathophysiologie, Uni Mainz

Zeitschrift:
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Stroke 1998: 29(11), 2412-2420

Land:
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Deutschland

Art der Veröffentlichung:
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Fachzeitschrift

Dokumenten-ID:
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2570


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Dokument 2567Titel:
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Complement C6 deficiency protects against diet-induced artherosclerosis in rabbits
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Bereich:
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Arterioskleroseforschung
Tiere:
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Warning: Use of undefined constant tieranzahl - assumed 'tieranzahl' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 535
12
Warning: Use of undefined constant tierart_id - assumed 'tierart_id' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 535
Kaninchen
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Jahr: 1998

Versuchsbeschreibung:
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Kaninchen erhalten 14 Wochen lang eine cholesterinreiche Diät. Blutproben zur Cholesterinbestimmung werden genommen. Dann erfolgt die Tötung.

Bereich:
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Warning: Use of undefined constant bereiche - assumed 'bereiche' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 543
Arterioskleroseforschung

Originaltitel: Complement C6 deficiency protects against diet-induced artherosclerosis in rabbits

Autoren:
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Walther Schmiedt (1)* , Juliane Kilo (1) , Hellmut Oelert (1) , Olaf Naunen (2) , Hans-Peter Deigner (2) , Jürgen Metz (3) , Huse Kamencic (3) , Ralf Kinscherf (3) , Sucharit Bhakdi (4)

Institute:
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(1)*Klinik und Poliklinik für Herz-, Thorax- und Gefäßchirurgie, Uni Mainz, (2) Pharmazeutisch-Chemisches Institut, Uni Heidelberg, (3) Institut für Anatomie und Zellbiologie, Uni Heidelberg, und (4) Institut für Medizinische Mikrobiologie und Hygiene, Uni Mainz

Zeitschrift:
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Arteriosclerosis, Thrombosis and Vascular Biology 1998: 18(11), 1790-1795

Land:
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Deutschland

Art der Veröffentlichung:
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Fachzeitschrift

Dokumenten-ID:
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2569


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Dokument 2568Titel:
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Überprüfung der Läsionsgefahr des N.ischiadicus des Kaninchens durch die Applikation niedrig- und mittelenergetischer extrakorporaler Stoßwellen
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Bereich:
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Orthopädie
Tiere:
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Warning: Use of undefined constant tieranzahl - assumed 'tieranzahl' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 535

Warning: Use of undefined constant tieranzahl - assumed 'tieranzahl' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 535
41
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Kaninchen
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Jahr: 1998

Versuchsbeschreibung:
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Bei Kaninchen wird in Narkose der Ischiasnerv einer Stoßwellenbehandlung unterzogen, um eine mögliche Schädigung des Nervs festzustellen. Nach spätestens 28 Tagen erfolgt die Tötung. Aus der Humanmedizin liegen keine Anhaltspunkte für eine Schädigung von Nervenfasern nach Stoßwellenbehandlung vor. Das wird durch das Tierexperiment bestätigt.

Bereich:
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Warning: Use of undefined constant bereiche - assumed 'bereiche' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 543
Orthopädie

Originaltitel: Überprüfung der Läsionsgefahr des N.ischiadicus des Kaninchens durch die Applikation niedrig- und mittelenergetischer extrakorporaler Stoßwellen

Autoren:
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J.-D. Rompe (1)* , M. Schwitalle (1) , O. Krischek (1) , J. Bohl (2) , H.-M. Riehle (3)

Institute:
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(1)*Orthopädische Klinik, Uni Mainz, (2) Abteilung für Neuropathologie, Institut für Pathologie, Uni Mainz, und (3) Institut für Pathologie, Uni Mainz

Zeitschrift:
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Zeitschrift für Orthopädie und ihre Grenzgebiete 1998: 136, 407-411

Land:
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Deutschland

Art der Veröffentlichung:
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Fachzeitschrift

Dokumenten-ID:
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2568


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Dokument 2569Titel:
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Characterisation of a Cryptosporidium parvum-specific cDNA clone and detection of parasite DNA in mucosal scrapings of infected mice
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Bereich:
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Parasitologie
Tiere:
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Mäuse (Anzahl unbekannt)
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(
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Anzahl unbekannt)
Jahr: 1998

Versuchsbeschreibung:
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Mäuse werden mit einem einzelligen Parasiten infiziert, dann werden sie getötet und der Darm auf den Gehalt von Parasiten überprüft.

Bereich:
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Warning: Use of undefined constant bereiche - assumed 'bereiche' (this will throw an Error in a future version of PHP) in /www/htdocs/w00ea1bb/aerzteneu/Backup/Kopie/datenbank-ergebnis.php on line 543
Parasitologie

Originaltitel: Characterisation of a Cryptosporidium parvum-specific cDNA clone and detection of parasite DNA in mucosal scrapings of infected mice

Autoren:
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Friedrich Zywietz (1)* , Vincent McDonald (2) , Michael A. Miles (2) , Martin W. Shirley (3)

Institute:
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(1)*Institut für Medizinische Mikrobiologie und Hygiene, Uni Mainz, (2) London School of Hygiene and Tropical Medicine, London, UK, und (3) Institute for Animal Health, Compton, Berkshire, UK

Zeitschrift:
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Molecular and Biochemical Parasitology 1998: 95, 21-31

Land:
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Deutschland

Art der Veröffentlichung:
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Fachzeitschrift

Dokumenten-ID:
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2567


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Dokument 2570Titel:
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Methotrexate specifically modulates cytokine production by T cells and macrophages in murine collagen-induced arthritis (CIA): a mechanism for methotrexate-mediated immunosuppression
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Bereich:
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Immunologie, Rheumatologie
Tiere:
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Mäuse (Anzahl unbekannt)
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(
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Anzahl unbekannt)
Jahr: 1999

Versuchsbeschreibung:
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An transgenen und anderen Mäusen werden schmerzhafte Gelenkentzündungen durch Injektion eines Eiweißstoffes erzeugt. An diesen sog. "Arthritismodellen" wird der Wirkungsmechanismus eines Medikamentes untersucht.

Bereich:
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Immunologie, Rheumatologie

Originaltitel: Methotrexate specifically modulates cytokine production by T cells and macrophages in murine collagen-induced arthritis (CIA): a mechanism for methotrexate-mediated immunosuppression

Autoren:
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Markus F. Neurath (1)* , K. Hildner (1) , C. Becker (1) , J.F. Schlaak (1) , K. Barbulescu (1) , Christian Meyer zum Büschenfelde (1) , E. Märker-Hermann (1) , G. Kollias (2) , M. Pasparakis (2) , S. Haralambous (2) , Edgar Schmitt (3) , T. Germann (3) , Peter Schirmacher (4)

Institute:
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(1)*Labor für Immunologie, Medizinische Klinik I, Uni Mainz, (2) Hellenic Pasteur Institute, Athen, Griechenland, (3) Institut für Immunologie, Uni Mainz, und (4) Institut für Pathologie, Uni Mainz

Zeitschrift:
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Clinical and Experimental Immunology 1999: 115, 42-55

Land:
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Deutschland

Art der Veröffentlichung:
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Fachzeitschrift

Dokumenten-ID:
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2566


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